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Role of exercise training on insulin resistance and TNF-α in high-fat diet rats
Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 403-407 doi: 10.1007/s11684-009-0071-0
关键词: exercise training insulin resistance tumor necrosis factor-α
Importance of emulsions in crystallization—applications for fat crystallization
Sandra PETERSEN, K. CHALEEPA, Joachim ULRICH
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 43-48 doi: 10.1007/s11705-013-1309-6
关键词: emulsion fat crystallization phase change material emulsion fractionation emulsion solidification
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 266-276 doi: 10.1007/s11684-017-0530-y
Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet–induced postnatal childhood obesity and puberty.
关键词: postnatal HFD feeding obesity kisspeptin HPG axis precocious puberty
Multiple effects of grape seed polyphenolics to prevent metabolic diseases
Torey ARVIK, Hyunsook KIM, James SEIBER, Wallace YOKOYAMA
《农业科学与工程前沿(英文)》 2018年 第5卷 第3期 页码 351-361 doi: 10.15302/J-FASE-2018235
Obesity is increasing in developing countries. Population studies show a relationship between affluence and obesity. Changing food intake patterns with affluence such as preference for foods with less astringent polyphenolic compounds and dietary fibers may increase risk of metabolic dysfunctions due to caloric imbalance. Animal models of obesity consistently show that grape seed procyanidins prevent increases in body and abdo- minal adipose weight gain, plasma cholesterol, liver weight gain and inflammation in animals on high fat diets. The mechanisms are not clear because the oral intake of procyanidins results in pleiotropic interactions with proteins in the mouth, stomach, small intestine, cecum and colon that affect the rate of digestion of bioavailability of macronutrients, sterols, and dietary fiber. Procyanidins also bind bile acids and reduce intestinal permeability to inflammatory bacterial cell wall fragment. Procyanidins are not degraded or metabolized until reaching the lower gut where they can be metabolized into phenolic acids by gut bacteria. While they are metabolized by gut bacteria, they also alter total numbers and distribution of phyla and species of gut bacteria. Gut bacteria are recognized as significant contributors to obesity and obesity related metabolic diseases. The review examines the different pleiotropic effects of grape seed procyanidins that have a significant effect on metabolic disease in animal models of obesity.
关键词: grape seed obesity procyanidins high fat microbiota animal models
Brown and beige fat: the metabolic function, induction, and therapeutic potential
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 162-172 doi: 10.1007/s11684-015-0382-2
Adipose tissue is an important organ for energy homeostasis. White adipose tissue stores energy in the form of triglycerides, whereas brown adipocytes and recently identified beige adipocytes are specialized in dissipating energy by thermogenesis or contribution to dispose glucose and clear triglycerides in blood. The inverse correlation between the brown adipose tissue activity and body mass suggests its protective role against body fat accumulation. Thus, recruitment and activation of brown or beige adipose tissue become particularly appealing targets for increasing energy expenditure. Angiogenesis and sympathetic nerve signals are the fundamental determinants for brown and beige adipose tissue development, as well as for their metabolic functions. Secretary factors including BMPs can induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic development.
《医学前沿(英文)》 doi: 10.1007/s11684-023-0999-5
关键词: thyroid carcinoma mesenchymal stem cell extracellular vesicle GTF2I FAT1 CDK4
Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 335-341 doi: 10.15302/J-FASE-2017152
关键词: Duroc pigs genome-wide association analysis intramuscular fat
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 146-161 doi: 10.1007/s11684-014-0373-8
Obesity prevalence has increased in recent years. Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesity. The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research. As of this writing, more than 73 obesity susceptibility loci have been identified in ethnic groups through GWAS. The identified loci explain only 2% to 4% of obesity heritability, thereby indicating that a large proportion of loci remain undiscovered. Thus, the next step is to identify and confirm novel loci, which may exhibit smaller effects and lower allele frequencies than established loci. However, achieving these tasks has been difficult for researchers. GWAS help researchers discover the causal loci. Moreover, numerous biological studies have been performed on the polygenic effects on obesity, such as studies on fat mass- and obesity-associated gene (FTO), but the role of these polygenic effects in the mechanism of obesity remains unclear. Thus, obesity-causing variations should be identified, and insights into the biology of polygenic effects on obesity are needed.
关键词: obesity genetics genome-wide association studies body mass index fat mass- and obesity-associated gene
酶法合成sn-2棕榈酸甘油酯的研究进展 Review
韦伟, 孙聪, 王小三, 金青哲, Xuebing Xu, Casimir C. Akoh, 王兴国
《工程(英文)》 2020年 第6卷 第4期 页码 406-414 doi: 10.1016/j.eng.2020.02.008
人乳脂(human milk fat, HMF)是婴儿重要的能量和营养来源,甘油三酯(TAG)在人乳脂中的含量约为98%,其具有独特的分子结构
Effect of different high viscosity modifiers on rheological properties of high viscosity asphalt
《结构与土木工程前沿(英文)》 2021年 第15卷 第6期 页码 1390-1399 doi: 10.1007/s11709-021-0775-z
关键词: high viscosity asphalt rheological properties rubber modifier viscosity
Continuous deacylation of amides in a high-temperature and high-pressure microreactor
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1818-1825 doi: 10.1007/s11705-022-2182-y
关键词: amide deacylation microreactor flow chemistry reaction intensification
《农业科学与工程前沿(英文)》 2023年 第10卷 第3期 页码 403-423 doi: 10.15302/J-FASE-2022471
● Methane production from fresh straw was 7.50% higher than dry straw.
关键词: fresh corn straw high solid anaerobic digestion metagenomics microbial communities thermophilic
Localized high-concentration electrolytes for lithium metal batteries: progress and prospect
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1354-1371 doi: 10.1007/s11705-022-2286-4
关键词: high-concentration electrolyte localized high-concentration electrolyte lithium metal battery solid electrolyte interphase dendrite
Approaches to achieve high grain yield and high resource use efficiency in rice
Jianchang YANG
《农业科学与工程前沿(英文)》 2015年 第2卷 第2期 页码 115-123 doi: 10.15302/J-FASE-2015055
关键词: rice nitrogen-efficient cultivar grain fill harvest index nitrogen use efficiency water use efficiency
标题 作者 时间 类型 操作
Role of exercise training on insulin resistance and TNF-α in high-fat diet rats
Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,
期刊论文
Importance of emulsions in crystallization—applications for fat crystallization
Sandra PETERSEN, K. CHALEEPA, Joachim ULRICH
期刊论文
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a
null
期刊论文
Multiple effects of grape seed polyphenolics to prevent metabolic diseases
Torey ARVIK, Hyunsook KIM, James SEIBER, Wallace YOKOYAMA
期刊论文
Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1
期刊论文
Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular fat
Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG
期刊论文
Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies
null
期刊论文
Effect of different high viscosity modifiers on rheological properties of high viscosity asphalt
期刊论文
METAGENOMICS COMBINED WITH HIGH-THROUGHPUT SEQUENCING REVEALS THE METHANOGENIC POTENTIAL OF FRESH CORNSTRAW UNDER THERMOPHILIC AND HIGH OLR
期刊论文